Alzheimer's Disease Research

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IMRIC, the Hebrew University of Jerusalem

In our IMRIC lab, we are trying to solve a puzzle.

We know that in the course of a cell's lifetime, toxins build up which can impair or drastically alter cellular function. But the real puzzle is why some toxins only start to build up late in life. For example, members of families with a history of Alzheimer's disease seem to develop it at around the same age — late in life. Where is the disease until then?

At IMRIC, we discovered that by slowing the aging process we can slow down the build-up of toxins, thereby slowing down progression of Alzheimer's and Alzheimer's-like diseases.  Ultimately we hope that this research will not only translate into slowing down the degenerative process, but prevent it entirely. 

Lastest news

by Rhonda Spivak, posted Dec 20, 2011

In order to understand Alzheimer’s disease, you have to think of chicken soup!

When you make chicken soup, you get all those oil drops that start to form together until you get one big glob of fatty oil. This happens when the oil drops form aggregates.

In a study recently published in the Journal of Neuroscience, Hebrew University of Jerusalem researchers, along with others from Israel and the US, presented their findings of a previously undescribed cellular mechanism which is essential for keeping cellular calcium concentration low.

 

Israeli researchers at The Institute for Medical Research Israel-Canada (IMRIC) at Hebrew U say a new material they are developing that inhibits the aging process could prevent degenerative diseases without affecting lifespan.

A step toward development of drugs for diseases like Alzheimer's, Parkinson's and Huntington's

Deciphering the mechanism that underlies the development of Alzheimer's disease in certain families but not in others, researchers at the Hebrew University of Jerusalem’s Faculty of Medicine have proposed that the malady is actually a collection of diseases that probably should be treated with a variety of different approaches.

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