No one is immune to the effects of the world’s most pressing medical challenges. And none of these challenges are immune to the brilliance and dedication of IMRIC’s researchers. Get to know them a little better by checking out their bios.
I want to understand more about cancer — how it grows and how to treat it
Our research at IMRIC has given us new understanding of the different forms of cancer.
Most of the projects in our lab involve animal models of cancer. Using genetically engineered mice, we are learning to identify tumor initiation and progression in different cancer models including liver, prostate, germ cell, breast and gastrointestinal cancer.
What we learn from these projects will help us better understand tumor initiation and growth, and lead to better treatment across the spectrum of cancers.
Throughout my academic life I have consistently enjoyed great science teachers. First and foremost, I had charismatic science teachers in both elementary and high school. Later on, I found the brilliant lecturers I had encountered, during my undergraduate biology studies at the Hebrew University of Jerusalem, highly inspirational. I was, furthermore, lucky to carry out my PhD research under the mentorship and guidance of distinguished Professor Howard Cedar at the Hebrew University’s Faculty of Medicine. Finally, I had the privilege of training as a Postdoctoral Fellow in the laboratory of Professor David Ish-Horowicz, a Fellow of the Royal Society, at Oxford University and Cancer Research, UK.
It was clear to me that I would like to establish my own laboratory, as an independent group leader, in the Faculty of Medicine at the Hebrew University. Here at IMRIC, besides teaching undergraduates and pursuing my research interests, I aim to serve as a role model to my graduate students, in whom I try to trigger the motivation and excitement I had enjoyed so much during my scientific education.
With regards to research, the objective of our investigations is to understand how signals, transmitted by the cell’s various transduction pathways, stimulate transcription factors to activate or repress the expression of their target genes. Specifically, we explore how signaling mediated by the EGF receptor pathway, that is tightly linked to human cancer (e.g., breast, lung and melanoma), impacts on gene regulation.
After my military service I decided to focus on biology, since it looked very interesting. Upon my graduation I reflected on my years of study and realized how much I thoroughly enjoyed doing my research and investigations. I also knew that I loved to teach. Taking both of these issues into account I understood that the best place for me to further my career and passion for science would be at the Hebrew University. The university lifestyle would be a perfect match for me.
Fortunately, I was given the opportunity to make my dream come true and follow my own stimulating scientific questions, establish a research group of wonderful students and make important discoveries.